Search results for " Anubi"
showing 3 items of 3 documents
Data from: Moving in the Anthropocene: global reductions in terrestrial mammalian movements
2019
Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects no…
Dèi d'Oriente, miti d'Oriente: icone e simboli nella poesia di Properzio
2016
Nei riguardi delle divinità orientali l'elegia di Properzio assume un atteggiamento di distacco ideologico piuttosto marcato, tanto più significativo in quanto, ad es., la figura di Bacco/Dioniso aveva trovato sia nella produzione bucolica sia in quella didascalica di Virgilio, oltre che nella lirica oraziana, significativa accoglienza negli anni in cui Ottaviano andava costruendo la propria immagine politica e traeva dal battage antoniano icone e simboli da introdurre all'interno della propria pubblicistica. La ripetuta presenza del dio tracio nella raccolta di Properzio diviene pertanto occasione preziosa per imbastire soprattutto sceneggiature metaletterarie o evocare quadri di investitu…
Image-Guided Synthesis Reveals Potent Blood-Brain Barrier Permeable Histone Deacetylase Inhibitors
2014
Recent studies have revealed that several histone deacetylase (HDAC) inhibitors, which are used to study/treat brain diseases, show low blood-brain barrier (BBB) penetration. In addition to low HDAC potency and selectivity observed, poor brain penetrance may account for the high doses needed to achieve therapeutic efficacy. Here we report the development and evaluation of highly potent and blood-brain barrier permeable HDAC inhibitors for CNS applications based on an image-guided approach involving the parallel synthesis and radiolabeling of a series of compounds based on the benzamide HDAC inhibitor, MS-275 as a template. BBB penetration was optimized by rapid carbon-11 labeling and PET im…